Yes. We have designed PlayoutONE with 4 on screen players and each player can output to any audio device on your machine. There is also a 5th device which is for editing and previewing audio this can go through it’s own device as well. You may want everything to go through just one device – this is also supported.
PlayoutONE 2.1 also supports 7.1 Surround Sound cards. So you can have multiple outputs from a simple sound card without spending hundreds on a multi headed sound card.